![]() In the case of the Institute quest line, speaking to Allie to start the Mass Fusion quest will pop up a nice warning stating you're about to become permanently hostile to the Brotherhood of Steel. The actual point of no return varies by faction alignment. The game is seemingly inconsistent in warning you when you're about to make permanent changes to your faction reputations. It is possible to reconnect with the factions you didn't choose after completing Institutionalized though. ![]() The Molecular Level quest both is and isn't a point of no return, fundamentally it requires you to make a choice - what you do need to consider is that speaking to a faction will provide you the infiltration quest for the Institute but also make the equivalent quest for the other factions unavailable.
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